The aim of this project is two-fold: first, to explore potential causal pathways for diseases and associated complications related to choices in the delivery of healthcare and health associated behaviors; and second, to understand how these potential causal pathways may affect healthcare costs. To address these research questions, we seek to analyze claims both at individual and population levels to determine if there are key factors – such as age, sex, and geography -- which may contribute to increased risk for certain conditions. The contribution of this research will be to help shape the way risk is understood and mitigated, including promoting the deployment of targeted preventative healthcare interventions (such as risk management tools, strategies, and programs) to avoid costly and unnecessary healthcare utilization. We hope that this research and development can be used for a variety of purposes, notably, in identifying populations early that require more concentrated interventions to prevent disease and disease complications.